Too many people diagnosed with depression are bipolar and don’t know it

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These two illnesses share the symptoms of depression. But they are not treated in the same way, with the risk of worsening the patient’s condition. Le Figaro” takes stock on the occasion of World Bipolar Disorder Day.

These two illnesses are seemingly so similar that it is very difficult to differentiate them. This confusion can be dramatic for patients. “Many studies show that treating bipolar disorder with an antidepressant alone worsens the illness, increases the frequency of relapses and the risk of suicide, warns Professor Raoul Belzeaux, a psychiatrist at Montpellier University Hospital. However, while the search for the correct diagnosis is a priority, studies show that 10 to 40% of patients diagnosed with depression auffer from bipolar disorder. This is a pitfall that must be avoided, Professor Belzeaux, a specialist in bipolar disorders, explains to Le Figaro on the occasion of World Bipolar Disorder Day.

Age of onset and occurrence of a manic phase

We should not admit defeat, however, because bipolar disorders leave clues. The first is the age at which the first symptoms appear, generally between 15 and 25 years old. While this illness is very heterogeneous, certain signs are quite suggestive. It generally begins with a depressive episode. From there, we must watch for the possible appearance of a so-called “manic” phase, characterized by an exaltation of mood, as we explained in a previous article  “Bipolar disorders and depressive disorders have depression in common. But it is the occurrence of at least one manic phase that will reide the diagnosis,” emphasizes Professor Belzeaux. This manic phase can, however, be very short-lived (only a few days) and very mild (we then speak of “hypomania”), far from the spectacular image that we have of it, which makes the illness even more difficult to identify. Unlike what happens in classic depression, the depressive phases of bipolar disorder have abrupt developments. “The beginning and end of these episodes are generally quite abrupt,” explains the psychiatrist. Schematically, the illness manifests itself by an alternation of manic, hypomanic, depressive, and mixed phases. A minority of patients have as many manic as depressive episodes, but the majority suffer more from depressive episodes. In any case, the recurrence of highs and lows (or only lows) should point to bipolar disorder.

Family history

Another clue: the existence of cases in the family. “The fact that other members of the family have been diagnosed with bipolar disorder or that there is a history of suicide should raise suspicions,” warns Professor Belzeaux. In addition, certain symptoms can lead one to suspect this illness rather than depression. “Having depressive phases accompanied by hypersomnia is very characteristic, as is weight gain,” informs the psychiatrist. Similarly, bipolar people are more vulnerable to addictions (particularly to alcohol, tobacco, cannabis, or cocaine): nearly half of patients are affected. Among the indicators that tip the scales toward bipolar disorder is also the patient’s response to treatment. “When antidepressants don’t work or work too well, meaning they seem to take effect within a few days, that’s a strong signal, even if it’s not enough to make the diagnosis,” says Professor Belzeaux.

No antidepressants for bipolar disorder

Depression and bipolar disorder are not treated in the same way. Traditionally, depression is treated by combining an antidepressant with psychotherapy, while bipolar disorder is treated with a mood-regulating medication, such as lithium. “Prescribing an antidepressant increases the instability of the illness, worsens the prognosis, and exposes the patient to the risk of relapse,” the psychiatrist emphasizes.

With his team, the doctor is working on developing a test that could guide diagnosis with just a blood test. “We will soon begin a clinical study at the Montpellier University Hospital to test the effectiveness of biomarkers, but we still have several months of work ahead of us before we can talk about possible commercialization,” explains the doctor. An innovation that could one day make life easier for patients who are still unaware of their condition and for those who will be.

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